Product Name:Quinine
CAS:130-95-0
MF:C20H24N2O2
MW:324.42
EINECS:205-003-2
Appearance: White powder
Quinine is one of the oldest antimalarial drugs. As early as the 15th century, people widely used cinchona bark, which contains quinine, to treat malaria. Its antimalarial effect resembles chloroquine because both interfere with DNA synthesis.
Specifically, quinine inhibits the erythrocytic stage of various Plasmodium parasites. Therefore, it can control malaria symptoms effectively. It also kills gametes of vivax and quartan malaria. However, it has no effect on the exoerythrocytic stage.
A major advantage is its low tendency to produce drug resistance. This likely occurs because quinine binds to plasmodium DNA differently than chloroquine. Consequently, no cross-resistance appears. Thus, doctors can use it to treat infections from chloroquine-resistant strains, especially Plasmodium falciparum.
Additionally, quinine excites the uterus and inhibits the myocardium. It also provides antipyretic and analgesic effects.
Beyond medicine, quinine has other uses. In analytical chemistry, it serves as a detection agent for metal ions like bismuth and platinum. Furthermore, it acts as a separating agent for racemic organic acids.
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