Isotretinoin

Isotretinoin is used primarily for severe cystic acne and acne that has not responded to other treatments. But it is not indicated for treatment of prepubertal acne and is not recommended in children less than 12 years of age.

It is also somewhat effective for hidradenitis suppurativa and some cases of severe rosacea. It can also be used to help treat harlequin ichthyosis, lamellar ichthyosis and is used in xeroderma pigmentosum cases to relieve keratoses. Isotretinoin has been used to treat the extremely rare condition fibrodysplasia ossificans progressiva. It is also used for treatment of neuroblastoma, a form of nerve cancer.