Camptothecin

Camptothecin was originally isolated from the stems of Camptotheca acuminata and showed anti-leukemia and anti-tumor activities. It derivatives mainly include Topotecan (Topotecan, TPT) and Irinotecan Hydrochloride (Irinotecan, CPT-1).

Camptothecin is a potent chemotherapy agent. This compound originates from the bark of the Camptotheca acuminata tree, also known as the “happy tree.” Initially, traditional Chinese medicine used extracts from this tree. However, modern science later isolated the pure chemical.

The drug works by targeting a crucial enzyme called topoisomerase I. This enzyme normally helps DNA unwind for replication and repair. Camptothecin binds to the enzyme-DNA complex. Consequently, it creates a lethal blockage. This action prevents cancer cells from dividing. Ultimately, the cells undergo programmed death.

Importantly, camptothecin itself has significant limitations. For example, it shows poor water solubility. Furthermore, it causes severe side effects. Therefore, researchers developed synthetic analogues. Specifically, irinotecan and topotecan are two successful derivatives. Today, doctors widely use these drugs against colorectal, lung, and ovarian cancers.

Recent studies continue to explore its potential. For instance, scientists are designing new delivery methods like nanoparticles. Additionally, they are testing combination therapies with other drugs. This ongoing research aims to enhance efficacy and reduce toxicity.

In summary, camptothecin serves as a foundational anticancer drug. Its unique mechanism inspired a major class of chemotherapy. Although the natural compound has challenges, its derivatives have saved countless lives. Ultimately, this natural product remains a cornerstone in oncology drug development.

Camptothecin FAQ:

1.Can I get Documentation for the products you sell?

You can reach out to us via email or Whatsapp message to request of MSDS or C0A. We do not have CoA for all the products we stock, but MSDS documents are available for all products.

2.Could I get sample of it?

Of course, sometimes we could supply free sample like 10g. If you need more, sample cost should be paide by your side.

3.How about the storage conditions of it?

Normally need dry and dark at room temperature.

4.Is best price or competitive price available from Oner Biotech?

We cannot guarantee that all our products are at the best prices, as price corresponds to the quality. However, we will do our best to support every customer by providing the best possible quality at a price you are satisfied with.

5.How much does shipping cost?

It depends on your location and chosen method.

6.How long will delivery take?
3-5 days by air, 5-7 days by FedEx, 30 days by sea.

7.Can I track my order?
Yes, we will send you the tracking number or BL/AWB number.