7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin is mainly used in the preparation of Irinotecan hydrochloride, the intermediate of Irinotecan.

7-Ethyl-10-hydroxycamptothecin, also known as SN-38, is a key pharmaceutical intermediate. First, it serves as the active metabolite of the prodrug Irinotecan. This compound directly inhibits the enzyme topoisomerase I. Consequently, it stabilizes the transient complex between DNA and the enzyme. This action causes irreversible DNA damage during replication. Ultimately, this process leads to cell death in rapidly dividing cells.

Furthermore, SN-38 is central to anticancer therapy. Specifically, it treats colorectal cancer and other solid tumors. Its mechanism provides a potent cytotoxic effect. Moreover, researchers value it for its high biological activity. However, the compound faces a significant challenge. It has very poor solubility in water. This property complicates its direct clinical formulation.

Therefore, scientists use it primarily as an intermediate. They chemically link it into prodrugs like Irinotecan. These prodrugs allow for effective administration into the body. Subsequently, the body’s enzymes convert the prodrug back into active SN-38. This strategy overcomes the solubility problem. Additionally, it ensures the compound reaches its target site.

In summary, 7-Ethyl-10-hydroxycamptothecin is a crucial bioactive agent. Its role enables the efficacy of important chemotherapies. Ongoing research continues to explore new delivery systems. For example, nanoparticle conjugates and antibody-drug hybrids show promise. Finally, this work aims to improve cancer treatment and reduce side effects.

FAQ:

1.Can I get Documentation for the products you sell?

You can reach out to us via email or Whatsapp message to request of MSDS or C0A. We do not have CoA for all the products we stock, but MSDS documents are available for all products.

2.Could I get sample of it?

Of course, sometimes we could supply free sample like 10g. If you need more, sample cost should be paide by your side.

3.How about the storage conditions of it?

Normally need dry and dark at room temperature.

4.Is best price or competitive price available from Oner Biotech?

We cannot guarantee that all our products are at the best prices, as price corresponds to the quality. However, we will do our best to support every customer by providing the best possible quality at a price you are satisfied with.

5.How much does shipping cost?

It depends on your location and chosen method.

6.How long will delivery take?
3-5 days by air, 5-7 days by FedEx, 30 days by sea.

7.Can I track my order?
Yes, we will send you the tracking number or BL/AWB number.